Dear Petra,

Here is a history for 4 GP138 genes.
First, a glycoprotein of 138 KDa was found as a target protein for cell fusion-blocking antibodies. Two genes possibly encoding it were isolated and named GP138A and GP138B. Then, the protein itself was shown to be present as isoforms, being renamed DdFRP1alpha, -1beta, -2 and -3. Later, two more paralogous genes,GP138C and GP138D, were identified and we have altogether four genes now. The relationship between those genes and proteins are;
	GP138D <-> DdFRP1alpha
	GP138C <-> DdFRP1beta
	GP138A <-> DdFRP2
	GP138B <-> DdFRP3
Reference: Hata et al., 2001. Gene 271:33-42.

It would be sound if we could move GP138 to frp after DdFRP (FRP stands for Fusion-Related Protein). Unfortunately, however, there is already frp for Fimbrin-Related Protein.

My suggestion is to change GP138 to cfr (cell fusion related) as an alternative to frp.
	cfrA <-> GP138A <-> DdFRP2
	cfrB <-> GP138B <-> DdFRP3
	cfrC <-> GP138C <-> DdFRP1beta
	cfrD <-> GP138D <-> DdFRP1alpha
I feel like it better than gp138 which has been used for a protein.

Best
Hideko


From: DICTY [mailto:[log in to unmask]] On Behalf Of Petra Fey
Sent: Friday, January 15, 2010 4:21 AM
To: [log in to unmask]
Subject: [DICTY - 263] gene nomenclature proposal

Dear Colleagues,
 
In an effort to be more consistent with gene nomenclature, the dictyBase curators would like to make all gene name prefixes lower case. Most gene names in dictyBase already follow this rule, but there are a few exceptions we propose to change, for example:
 
- CSN1 to csn1
- CYP51 to cyp51
- Dd5P4 to dd5p4
- GP138A to gp138A
- H2Av1 to h2av1
- PIPkinA to pipkinA
 
Please contact us with comments, concerns, or suggestions.
 
Thanks and best regards,
 
Petra, Pascale, Bob
http://dictybase.org