dictyNews
Electronic Edition
Volume 43, number 4
March 3, 2017

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Abstracts
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Functional interaction of PkcA and PldB regulate aggregation and 
development in Dictyostelium discoideum

Sean Singh, Wasima Mohamed, Annelie Aguessy, Ella Dyetta, Shriraj 
Shah, Mohammedasad Khan, Ramamurthy Baskar, Derrick Brazill,*


Cellular Signalling, in press

Multicellular development in Dictyostelium discoideum involves 
tightly regulated signaling events controlling the entry into development, 
initiation of aggregation and chemotaxis, and cellular differentiation. 
Here we show that PkcA, a Dictyostelium discoideum Protein Kinase 
C-orthologue, is involved in quorum sensing and the initiation of 
development, as well as cAMP sensing during chemotaxis. Additionally, 
by epistasis analysis we provide evidence that PkcA and PldB (a 
Phospholipase D-orthologue) functionally interact to regulate 
aggregation, differentiation, and cell-cell adhesion during development. 
Finally, we show that PkcA acts as a positive regulator of intracellular 
PLD-activity during development. Taken together, our results suggest 
that PkcA act through PldB, by regulating PLD-activity, in order to 
control events during development.


submitted by: Derrick Brazill  [[log in to unmask]]
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