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| Date: | Fri, 9 Dec 2011 22:19:21 +0000 |
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dictyNews
Electronic Edition
Volume 37, number 15
December 9, 2011
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to [log in to unmask]
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
Back issues of dictyNews, the Dicty Reference database and other
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=========
Abstracts
=========
Transcriptional Repression by a Bzip Protein Regulates Dictyostelium
Prespore Differentiation
Beatriz Nuņez-Corcuera, Joanna L. Birch, Yoko Yamada and
Jeffrey G. Williams+
College of Life Sciences, Welcome Trust Building, University of Dundee,
Dow St., Dundee DD1 5EH UK
PLoS One, in Press
In response to the signaling polyketide DIF-1 DimB directly activates
transcription of the ecmB gene in pstB cells; a subset of the prestalk cells
that are the precursors of the basal disc. We show that the promoter of
pspA, a prespore-specific gene, also contains a DimB binding site.
Mutation of this site causes ectopic expression in the prestalk region and
ChIP analysis shows that DIF-1 induces binding of DimB to the pspA
promoter. DIF-1 represses pspA gene expression in a suspension cell
assay but this repression is abrogated in a dimB null strain. These results
suggest a coupled control mechanism, whereby the same DIF-DimB
signaling pathway that directly activates ecmB gene expression directly
represses pspA gene expression.
Submitted by Jeff Williams [[log in to unmask]]
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[End dictyNews, volume 37, number 15]
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