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| Date: | Fri, 6 May 2011 16:36:13 -0500 |
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dictyNews
Electronic Edition
Volume 36, number 13
May 6, 2011
Please submit abstracts of your papers as soon as they have been
accepted for publication by sending them to [log in to unmask]
or by using the form at
http://dictybase.org/db/cgi-bin/dictyBase/abstract_submit.
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=========
Abstracts
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A SET/MYND chromatin re-modelling protein regulates Dictyostelium
prespore patterning
Beatriz Nuņez-Corcuera, Joanna Birch and Jeffrey G. Williams+
College of Life Sciences, Welcome Trust Building, University of
Dundee, Dow St.,Dundee DD1 5EH, UK
Short communication in Int J Dev Biol, in press
SmdA is a Dictyostelium orthologue of the SET/MYND chromatin
re-modelling proteins. In developing structures derived from a null
mutant for smdA (a smdA- strain) prestalk patterning is normal but using
a prespore lacZ reporter fusion there is ectopic accumulation of
B-galactosidase in the prestalk region. As wild type slugs migrate there
is continual forward movement and re-differentiation of prespore cells
into prestalk cells. Thus a potential explanation for the ectopic
reporter localization in smdA null prestalk cells is an increased rate
of re-differentiation and anterior movement of prespore cells. In
support of this notion analysis of an unstable lacZ reporter, driven by
the prespore promoter, reveals a normal staining pattern in the smdA-
strain. We suggest that one or more genes regulated by SmdA acts to
repress prespore re-specification.
Submitted by Jeffrey Williams [[log in to unmask]]
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[End dictyNews, volume 36, number 13]
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