dictyNews
Electronic Edition
Volume 44, number 3
January 26, 2018

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Abstracts
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Amplification of PIP3 signalling by macropinocytic cups

Robert R. Kay, Thomas D. Williams & Peggy Paschke


Biochem. J., in press

In a role distinct from and perhaps more ancient than that in signal 
transduction, PIP3 and Ras help to spatially organize the actin 
cytoskeleton into macropinocytic cups. These large endocytic 
structures are extended by actin polymerization from the cell 
surface and have at their core an intense patch of active-Ras and 
PIP3, around which actin polymerizes, creating cup-shaped
 projections. We hypothesise that active-Ras and PIP3 self-amplify 
 within macropinocytic cups, in a way that depends on the structural 
 integrity of the cup.  Signalling that triggers macropinocytosis may 
 therefore be amplified downstream in a way that depends on 
 macropinocytosis. This argument provides a context for recent 
 findings that signalling to Akt (an effector of PIP3) is sensitive to 
 cytoskeletal and macropinocytic inhibitors.


submitted by: Rob Kay  [[log in to unmask]]
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