dictyNews

Electronic Edition

Volume 46, number 14

May 22, 2020



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Abstracts

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Polar pattern formation induced by contact following locomotion in a 

multicellular system



Masayuki Hayakawa, Tetsuya Hiraiwa, Yuko Wada, Hidekazu Kuwayama, 

Tatsuo Shibata 





eLife 2020;9:e53609 DOI: 10.7554/eLife.53609

https://elifesciences.org/articles/53609



Biophysical mechanisms underlying collective cell migration of eukaryotic 

cells have been studied extensively in recent years. One mechanism that 

induces cells to correlate their motions is contact inhibition of locomotion, 

by which cells migrating away from the contact site. Here, we report that 

tail-following behavior at the contact site, termed contact following 

locomotion (CFL), can induce a non-trivial collective behavior in migrating 

cells. We show the emergence of a traveling band showing polar order in 

a mutant Dictyostelium cell that lacks chemotactic activity. We find that 

CFL is the cell–cell interaction underlying this phenomenon, enabling a 

theoretical description of how this traveling band forms. We further show 

that the polar order phase consists of subpopulations that exhibit 

characteristic transversal motions with respect to the direction of band 

propagation. These findings describe a novel mechanism of collective 

cell migration involving cell–cell interactions capable of inducing traveling 

band with polar order.





submitted by: Tatsuo Shibata   [[log in to unmask]

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[End dictyNews, volume 46, number 14]