dictyNews

Electronic Edition

Volume 43, number 22

September 22, 2017



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Abstracts

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Isolation, Synthesis and Biological Activity of Chlorinated 

Alkylresorcinols from Dictyostelium Cellular Slime Molds



Haruhisa Kikuchi1, Ikuko Ito1, Katsunori Takahashi2, Hirotaka 

Ishigaki2, Kyoichi Iizumi2, Yuzuru Kubohara2, Yoshiteru Oshima1



1Graduate School of Pharmaceutical Sciences, Tohoku University, 

6-3, Aza-Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.

2Department of Medical Technology, Faculty of Health Science, 

Gunma Paz University, 1-7-1, Tonyamachi, Takasaki 370-0006, Japan

3Graduate School of Health and Sports Science, Juntendo University, 

1-1 Hiraga-gakuendai, Inzai, Chiba 270-1695, Japan





J. Nat. Prod., in press.



Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were 

isolated from the fruiting bodies of Dictyostelium monochasioides. 

Compounds 1–8 were synthesized to confirm their structures and 

to obtain sufficient material for performing biological tests. 

Monochasiol A (1) selectively inhibited the concanavalin A-induced 

interleukin-2 production in Jurkat cells, a human T lymphocyte cell 

line. Monochasiols were biogenetically synthesized by the combination 

of biosynthetic enzymes relating to the principal polyketides, MPBD 

and DIF-1, produced by Dictyostelium discoideum.





submitted by: Haruhisa Kikuchi [[log in to unmask]]

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[End dictyNews, volume 43, number 22]